Product Identification Refex R 407C
Chemical Family Hydrofluorocarbons
Chemical Formula CH2F2/CHF2CF3/CF3CH2F
Chemical Name Difluoromethane/Pentafluoroethane/Tetrafluoroethane
Company Identification Refex Refrigerants Ltd – #114, Thandalam Village, Thiruporur, Kanchipuram 603 110 Tamilnadu, India
Phone +91-44-27445295/27445296, +91-9884397803
Email admin@refex.co.in




Material CAS Number %
PENTAFLUOROETHANE (HFC-125) 354-33-6 25 811-97-2
ETHANE, 1, 1, 1, 2-TETRAFLUORO- (HFC-134a) 52



Physical Data

Boiling Point -43.9 C (-47 F) Average
Vapour Pressure 171.8 psia 25 C (77 F)
%Volatiles 100 WT%
Evaporation Rate (Cl4 = 1)
Solubility in Water Not determined
Odor Slight ethereal
Form Liquefied gas
Color Clear, colorless
Specific Gravity 1.136 @ 25 C (77 F)



Potential Health Effects

Inhalation of high concentrations of vapor is harmful and may cause heart irregularities, unconsciousness, or death. Intentional misuse or deliberate inhalation may cause death without warning. Vapor reduces oxygen available for breathing and is heavier than air. Liquid contact can cause frostbite.


Overexposure to the vapors by inhalation may include temporary nervous system depression with anesthetic effects such as dizziness, headache, confusion, incoordination, and loss of consciousness. Higher exposures to the vapors may cause temporary alteration of the heart’s electrical activity with irregular pulse, palpitations, or inadequate circulation. Gross overexposure may be fatal. Skin contact with the liquid may cause frostbite. Individuals with preexisting diseases of the central nervous or cardiovascular system may have increased susceptibility to the toxicity of increased exposures.

Carcinogenicity Information

None of the components present in this material at concentrations equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH as a carcinogen.

First Aid


If inhaled, immediately remove to fresh air. Keep person calm. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.


Flush area with lukewarm water. Do not use hot water. If frostbite has occurred, call a physician.


In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Call a physician.


Not a probable route. However, in case of accidental ingestion, call a physician.
If vomiting occurs naturally, have victim lean forward to reduce the risk of aspiration.

Notes to Physicians

THIS MATERIAL MAY MAKE THE HEART MORE SUSCEPTIBLE TO ARRHYTHMIAS. Catecholamine such as adrenaline, and other compounds having similar effects, should be reserved for emergencies and then used only with special caution.



Fire Fighting Measures

Flash Point: No flash point
Flammable Limits in Air, % by Volume:
LEL: None per ASTM E681
UEL: None per ASTM E681
Autoignition: Not determined

Fire and Explosion Hazards

Cylinders may rupture under fire conditions. Decomposition may occur. Contact of welding or soldering torch flame with high concentrations of refrigerant can result in visible changes in the size and color of torch flames. This flame effect will only occur in concentrations of product well above the recommended exposure limit, therefore stop all work and ventilate to disperse refrigerant vapors from the work area before using any open flames. R-407C is not flammable in air at temperatures up to 100 deg C (212 deg F) at atmospheric pressure. However, mixtures of R-407C with high concentrations of air at elevated pressure and/or temperature can become combustible in the presence of an ignition source. R-407C can also become combustible in an oxygen enriched environment (oxygen concentrations greater than that in air). Whether a mixture containing R-407C and air, or R-407C in an oxygen enriched atmosphere becomes combustible depends on the inter-relationship of 1) the temperature 2) the pressure, and 3) the proportion of oxygen in the mixture. In general, R-407C should not be allowed to exist with air above atmospheric pressure or at high temperatures; or in an oxygen enriched environment. For example: R-407C should NOT be mixed with air under pressure for leak testing or other purposes.

Experimental data have also been reported which indicate combustibility of HFC-134a, a component in this blend, in the presence of chlorine.
Extinguishing Media
As appropriate for combustibles in area.

Fire Fighting Instruction

Cool tank/container with water spray. Self-contained breathing apparatus (SCBA) may be required if cylinders rupture or release under fire conditions. Water runoff should be contained and neutralized prior to release.


NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL) sections before proceeding with clean-up. Use appropriate PERSONAL PROTECTIVE EQUIPMENT during clean-up. Ventilate area, especially low or enclosed places where heavy vapors might collect. Remove open flames. Use self-contained breathing apparatus (SCBA) if large spill or leak occurs.


Use with sufficient ventilation to keep employee exposure below recommended limits. Handling (Physical Aspects) HFC-134a should not be mixed with air for leak testing or used for any other purpose above atmospheric pressure. See Flammable Properties section. Contact with chlorine or other strong oxidizing agents should also be avoided.


Store in a clean, dry place. Do not heat above 52 C (126 F).
Valve protection caps and valve cutlet threaded plugs must remain in place unless container is secured with valve outlet piped to use point. Do NOT drag, slide or roll cylinders. Use a suitable hand truck for cylinder movement. Never attempt to lift cylinder by its cap. Use a pressure reducing regulator when connecting cylinder to lower pressure (>3000 psig) piping or systems. Do NOT heat cylinder. Use a check valve or trap in the discharge line to prevent hazardous back flow into the cylinder. Cylinders should be stored upright and firmly secured to prevent falling or being knocked over. Separate full containers from empty containers. Storage area temperatures should not exceed 125 deg F (52 deg C) and should be free of combustible materials. Avoid area where salt or other corrosive materials are present. Avoid excessive inventory and storage time. Use a first-in first-out system. Keep accurate inventory records.

Waste Disposal

Contaminated HFC-134a can be recovered by distillation or removed to a permitted waste disposal facility.



Engineering Controls

Normal ventilation for standard manufacturing procedures is generally adequate. Local exhaust should be used when large amounts are released. Mechanical ventilation should be used in low or enclosed places. Refrigerant concentration monitors may be necessary to determine vapor concentrations in work areas prior to use of torches or other open flames, or if employees are entering enclosed areas.

Personal Protective Equipment

Impervious gloves and chemical splash goggles should be used when handling liquid. Under normal manufacturing conditions, no respiratory protection is required when using this product. Self-contained breathing apparatus (SCBA) is required if a large release occurs.

Exposure Guidelines

Exposure Limits

“REFEX” HFC 134a
PEL (OSHA): None Established
TLV (ACGIH): None Established
AEL * (Refex): 1000 ppm, 8 & 12 Hr. TWA
WEEL (AIHA): 1000 ppm, 8 Hr. TWA
AEL is Refex’s Acceptable Exposure Limit. Where governmentally imposed occupational exposure limits which are lower than the AEL are in effect, such limits shall take precedence.


Chemical Stability – STABLE

Conditions to Avoid – Avoid open flames and high temperatures.

Incompatibility with Other Materials – Incompatible with alkali or alkaline earth metals – powdered Al,
Zn, Be, etc.

Decomposition – Decomposition products are hazardous. This material can be decomposed by high temperatures (open flames, glowing metal surfaces, etc.) forming hydrofluoric acid and possibly carbonyl fluoride. These materials are toxic and irritating. Contact should be avoided.

Polymerization – Polymerization will not occur.



Animal Data

A short duration spray of vapor produced very slight eye irritation.


Animal testing indicates this material is a slight skin irritant, but not a skin sensitizer.


4 hour, ALC, rat: 567,000 ppm.

Single exposure caused: Cardiac sensitization, a potentially fatal disturbance of heart rhythm associated with a heightened sensitivity to the action of epinephrine.

Lowest-Observed-Adverse-Effect-Level for cardiac sensitization: 75,000 ppm. Single exposure caused: Lethargy. Narcosis. Increased respiratory rates. These effects were temporary.

Single exposure to near lethal doses caused: Pulmonary edema. Repeated exposure caused: Increased adrenals, liver, spleen weight. Decreased uterine, prostate weight. Repeated dosing of higher concentrations caused: the following temporary effects – Tremors. Incoordination.


In a two-year inhalation study, HFC-134a, at a concentration of 50,000 ppm, produced an increase in late-occurring benign testicular tumors, testicular hyperplasia and testicular weight. The no-effect-level for this study was 10,000 ppm. Animal data show slight fetotoxicity but only at exposure levels producing other toxic effects in the adult animal. Reproductive data on male mice show: No change in reproductive performance. Tests have shown that this material does not cause genetic damage in bacterial or mammalian cell cultures, or in animals. In animal testing, this material has not caused permanent genetic damage in reproductive cells of mammals (has not produced heritable genetic damage).



Ecotoxicological Information
48 hour EC50 – Daphnia magna: 980 mg/L
96 hour LC50 – Rainbow trout: 450 mg/L



Shipping Information

Shipping Containers Tank Cars.
Tank Trucks.

The data in this Material Safety Data Sheet relates only to the specific material designated herein and does not relate to use in combination with any other material or in any process.

Responsible for MSDS:

Refex Refrigerants Limited
#114, Thandalam Village,Thiruporur,
Kanchipuram Dt,603 110.
Tamilnadu, India.
Ph : +91-44-27445295/ 27445295

This information is based upon technical information believed to be reliable. It is subject to revision as additional knowledge and experience is gained.